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KMID : 0363219710090030023
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Korean Journal of Dermatology
1971 Volume.9 No. 3 p.23 ~ p.30
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Extramammary Paget´s Disease
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李正馥/Lee, Jung Bock
禹泰河/金貞淑/Woo, Tae Ha/Kim, Chung Sook
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Abstract
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Extramammary Paget´s disease is a dermatosis which pathologically and clinically resembles Paget´s disease of the breast. The disease occurs in regions with apocrine glands; most often in the anogenital area, seldom in the axilla. umbilicus, mucous membrane of the mouth, nose, ear and Moll´s gland of the eyelid.
In this work the effect of bleomycin for extramammary Paget´s disease was studied on ultrastructural aspect. The material was a case of extramammary Paget´s disease of 7 years standing occuring in the scrotum and the pubic area by serial sections after IV injection of 60mg, 120mg and 240mg of bleomycin, and examined under the electron microscope.
The results obtained are summarized as follows:
1. The size of Paget´s cell and its nucleus was gradually decreased.
2. The numbers of lysosome, dense body, autophagic vacuolization and tonofilament was decreased.
From these findings, it is suggested that bleomycin induces retrograde degenerative change of Paget´s cell, and cell necrosis finally.
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